Successful Amelioration of Mitochondrial Optic Neuropathy Using the Yeast NDI1 Gene in a Rat Animal Model

@inproceedings{Marella2010SuccessfulAO,
  title={Successful Amelioration of Mitochondrial Optic Neuropathy Using the Yeast NDI1 Gene in a Rat Animal Model},
  author={Mathieu Marella and Byoung Boo Seo and Biju B Thomas and Akemi Matsuno-Yagi and Takao Yagi},
  booktitle={PloS one},
  year={2010}
}
BACKGROUND Leber's hereditary optic neuropathy (LHON) is a maternally inherited disorder with point mutations in mitochondrial DNA which result in loss of vision in young adults. The majority of mutations reported to date are within the genes encoding the subunits of the mitochondrial NADH-quinone oxidoreductase, complex I. Establishment of animal models of LHON should help elucidate mechanism of the disease and could be utilized for possible development of therapeutic strategies. METHODOLOGY… CONTINUE READING
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Expression of the yeast NADH dehydrogenase Ndi1 in Drosophia confers increased lifespan independently of dietary restriction

  • A Sanz, H Soilihi, M Portero-Otin, A Wilson, E Kemppainen
  • Proc Natl Acad Sci U S A
  • 2010
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