Success of pyridostigmine, physostigmine, eptastigmine and phosphotriesterase treatments in acute sarin intoxication.

@article{Tuovinen1999SuccessOP,
  title={Success of pyridostigmine, physostigmine, eptastigmine and phosphotriesterase treatments in acute sarin intoxication.},
  author={Kai Tuovinen and E Kaliste-Korhonen and Frank M Raushel and Osmo H{\"a}nninen},
  journal={Toxicology},
  year={1999},
  volume={134 2-3},
  pages={169-78}
}
The acute toxicity of organophosphorus (OP) compounds in mammals is due to their irreversible inhibition of acetylcholinesterase (AChE) in the nervous system, which leads to increased synaptic acetylcholine levels. The protective actions of intravenously (i.v.) administered pyridostigmine, physostigmine, eptastigmine, and an organophosphate hydrolase, phosphotriesterase, in acute sarin intoxication were studied in mice. The acute intragastric (i.g.) toxicity (LD50) of sarin with and without the… CONTINUE READING

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Casarett and Doull’s Toxicology: The Basic Science of Poisons

  • D. J. Ecobichon
  • 1991
Highly Influential
4 Excerpts

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