Success and failure of vaccines against renin–angiotensin system components

@article{Brown2009SuccessAF,
  title={Success and failure of vaccines against renin–angiotensin system components},
  author={Morris J. Brown},
  journal={Nature Reviews Cardiology},
  year={2009},
  volume={6},
  pages={639-647}
}
  • Morris J. Brown
  • Published 1 October 2009
  • Biology, Medicine
  • Nature Reviews Cardiology
Therapeutic vaccination pre-dated modern drugs as a possible strategy for treating hypertension. This approach is now being rediscovered, through use of modified angiotensins as immunogens together with carriers and adjuvants. Effective blockade of the renin–angiotensin system (RAS) with treatment twice a year might suit patients who dislike taking drugs on a daily basis and would also be an attractive option for those who have blood pressures in the prehypertensive range, if it can prevent… 

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