Subversion of human intestinal mucosa innate immunity by a Crohn’s disease-associated E. coli

@article{Jarry2015SubversionOH,
  title={Subversion of human intestinal mucosa innate immunity by a Crohn’s disease-associated E. coli},
  author={Anne Jarry and Lise Cr{\'e}met and Nathalie Caroff and Chantal Bou-Hanna and J-M. Mussini and Annabelle Reynaud and Alain L. Servin and J F Mosnier and Vanessa Li{\'e}vin-Le Moal and Christian L. Laboisse},
  journal={Mucosal Immunology},
  year={2015},
  volume={8},
  pages={572-581}
}
Adherent-invasive Escherichia coli (AIEC), associated with Crohn’s disease, are likely candidate contributory factors in the disease. However, signaling pathways involved in human intestinal mucosa innate host response to AIEC remain unknown. Here we use a 3D model of human intestinal mucosa explant culture to explore the effects of the AIEC strain LF82 on two innate immunity platforms, i.e., the inflammasome through evaluation of caspase-1 status, and NFκB signaling. We showed that LF82… CONTINUE READING
BETA

Similar Papers

References

Publications referenced by this paper.
SHOWING 1-10 OF 51 REFERENCES

Recent advances in understanding enteric pathogenic Escherichia coli

Croxen, M.A
  • Clin. Microbiol. Rev
  • 2013

a translational study

Souaze, F. et al. Differential roles of Hath1, MUC2, P27Kip1 in relation with gamma-secretase inhibition in hum carcinomas
  • PloS One 8, e55904
  • 2013
VIEW 1 EXCERPT

a translational study

Souaze, F. et al. Differential roles of Hath1, MUC2, P27Kip1 in relation with gamma-secretase inhibition in hum carcinomas
  • PloS One 8, e55904
  • 2013
VIEW 1 EXCERPT

lessons from cultured, fully differentiated human colon cancer cell lines

V. Lievin-Le Moal, Servin, A. L. Pathogenesis of human enterovirulent bacteria
  • Microbiol. Mol. Biol. Rev. 77, 380–439
  • 2013
VIEW 1 EXCERPT

lessons from cultured, fully differentiated human colon cancer cell lines

V. Lievin-Le Moal, Servin, A. L. Pathogenesis of human enterovirulent bacteria
  • Microbiol. Mol. Biol. Rev. 77, 380–439
  • 2013
VIEW 1 EXCERPT