Subversion of host cell signalling by the protozoan parasite Leishmania

@article{Gregory2005SubversionOH,
  title={Subversion of host cell signalling by the protozoan parasite Leishmania},
  author={David J Gregory and Martin Olivier},
  journal={Parasitology},
  year={2005},
  volume={130},
  pages={S27 - S35}
}
The protozoa Leishmania spp. are obligate intracellular parasites that inhabit the macrophages of their host. Since macrophages are specialized for the identification and destruction of invading pathogens, both directly and by triggering an innate immune response, Leishmania have evolved a number of mechanisms for suppressing some critical macrophage activities. In this review, we discuss how various species of Leishmania distort the host macrophage's own signalling pathways to repress the… Expand
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