Subversion of actin dynamics by EPEC and EHEC.

  title={Subversion of actin dynamics by EPEC and EHEC.},
  author={Emmanuelle Caron and Valerie F Crepin and Nandi Simpson and Stuart Knutton and J. Gonz{\'a}lez Garmendia and Gad Frankel},
  journal={Current opinion in microbiology},
  volume={9 1},
During the course of infection, enteropathogenic and enterohaemorrhagic Escherichia coli (EPEC and EHEC, respectively) subvert the host cell signalling machinery and hijack the actin cytoskeleton to tighten their interaction with the gut epithelium, while avoiding phagocytosis by professional phagocytes. Much progress has been made recently in our understanding of how EPEC and EHEC regulate the pathways leading to local activation of two regulators of actin cytoskeleton dynamics, the Wiskott… CONTINUE READING


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