Subversion of NPC1 pathway of cholesterol transport by Anaplasma phagocytophilum.

  title={Subversion of NPC1 pathway of cholesterol transport by Anaplasma phagocytophilum.},
  author={Qingming Xiong and Yasuko Rikihisa},
  journal={Cellular microbiology},
  volume={14 4},
Intracellular cholesterol amounts, distribution and traffic are tightly regulated to maintain the healthy eukaryotic cell function. However, how intracellular pathogens that require cholesterol, interact with the host cholesterol homeostasis and traffic is not well understood. Anaplasma phagocytophilum is an obligatory intracellular and cholesterol-robbing bacterium, which causes human granulocytic anaplasmosis. Here we found that a subset of cholesterol-binding membrane protein, Niemann-Pick… CONTINUE READING


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