Subventricular zone‐derived neuronal progenitors migrate into the subcortical forebrain of postnatal mice

  title={Subventricular zone‐derived neuronal progenitors migrate into the subcortical forebrain of postnatal mice},
  author={Silvia De Marchis and Aldo Fasolo and Adam C. Puche},
  journal={Journal of Comparative Neurology},
The presence of a germinal layer and the capacity to generate neurons, once thought restricted to the embryonic brain, persists in the forebrain of both postnatal and adult mammals. The two regions in which this phenomenon has been extensively demonstrated are the hippocampal dentate gyrus and the lateral ventricle subventricular zone (SVZ). SVZ‐derived cells migrate along the rostral migratory stream into the olfactory bulb, where they differentiate into local interneurons. In this study… 

Neurogenesis and widespread forebrain migration of distinct GABAergic neurons from the postnatal subventricular zone

It is demonstrated that the SVZ is a reservoir of GABAergic interneurons not only for the OB, but also for other cortical and subcortical areas.

Neurogenesis of medium spiny neurons in the nucleus accumbens continues into adulthood and is enhanced by pathological pain

Using several in vivo mouse models, it is shown that newborn neurons integrate into preexisting circuits in the NAc where they mature as medium spiny neurons (MSNs), i.e., a type of projection neurons formerly believed to be generated only during embryonic development.

Regulation of subventricular zone-derived cells migration in the adult brain.

A better understanding of the factors that control the movement of newly generated cells may be crucial for improving the use of NSC-replacement therapy for specific neurological diseases.

SVZ-derived newly generated neurons populate several olfactory and limbic forebrain regions

Previous data were shown that mature newborn neurons are also found in these regions as indicated by double-labeling for NeuN and BrdU, and it is hypothesize that brain regions displaying adult neurogenesis are functionally linked.

Heterogeneous distribution of doublecortin‐expressing cells surrounding the rostral migratory stream in the juvenile mouse

Novel results provide highly precise morphological information for immature neurons and suggest that a portion of immature neurons may be detached from the RMS and migrate in various directions.

Neurogenesis in the Caudate Nucleus of the Adult Rabbit

The results suggest that neurogenesis in the caudate nucleus of rabbit is a phenomenon independent from that occurring in the adjacent subventricular zone, mostly attributable to the activity of clusters of proliferating cells located within the parenchyma of this nucleus.

Origin, migration and fate of newly generated neurons in the adult rodent piriform cortex

DiI tracing methods confirmed a migratory route to the piriform cortex from the ventricular subependyma, and the presence of BrdU/NeuN labeled cells as early as 7 days after a Brd U injection in mice and 10 days in the rat and lasting as long as 41 days indicates that some of these cells have extended survival durations in the adult Piriform cortex.

Extensive migration of young neurons into the infant human frontal lobe

Using high-resolution magnetic resonance imaging, histology, and time-lapse confocal microscopy, the migration of many young inhibitory interneurons around the dorsal anterior walls of the lateral ventricle and into multiple cortical regions of the human frontal cortex was observed.



Neurogenesis and neuronal migration in the neonatal rat forebrain anterior subventricular zone do not require GFAP-positive astrocytes.

The scarcity of glial markers in the neonatal SVZa indicates that the forebrain subventricular zone includes a distinct neurogenic anterior region containing predominantly committed neuronal progenitor cells, suggesting that astroglia are not involved in the generation or migration of most olfactory bulb interneurons.

Multiple Cell Populations in the Early Postnatal Subventricular Zone Take Distinct Migratory Pathways: A Dynamic Study of Glial and Neuronal Progenitor Migration

There are at least two distinct migratory pathways within the SVZ used differentially by immature neurons and glia, both of which are shown to give rise to olfactory interneurons or glia.

In utero fate mapping reveals distinct migratory pathways and fates of neurons born in the mammalian basal forebrain.

It is demonstrated that LGE and MGE cells migrate along different routes to populate distinct regions in the developing brain, and it is shown that the MGE is a major source of neurons migrating dorsally and invading the developing neocortex.

Early patterns of migration, morphogenesis, and intermediate filament expression of subventricular zone cells in the postnatal rat forebrain

Observations suggest that the expression of nestin and vimentin occurs after progenitors emigrate from the SVZ and that filament expression and contact with blood vessels represent an early stage of astrocyte differentiation.

The rostral migratory stream in adult squirrel monkeys: contribution of new neurons to the olfactory tubercle and involvement of the antiapoptotic protein Bcl‐2

The findings reveal that the RMS in New World monkeys is mitotically robust and markedly extended and suggest that Bcl‐2 might play a role in the survival and/or differentiation of newborn neurons destined to olfactory bulb and Olfactory tubercle in primates.

Long-distance neuronal migration in the adult mammalian brain.

Grafted and endogenous SVZ cells in the lateral ventricle of adult mice migrate long distances and differentiate into neurons in the olfactory bulb.

Divergent lineages for oligodendrocytes and astrocytes originating in the neonatal forebrain subventricular zone

D discrete groups of clonally related cells, generated by infecting progenitor cells of the neonatal subventricular zone with a retroviral lineage tracer, were analyzed ultrastructurally and found to give rise to both astrocytes and oligodends during the peak of gliogenesis.

Newly generated neurons in the amygdala and adjoining cortex of adult primates

The production of newborn neurons in the amygdala, piriform cortex, and inferior temporal cortex seems to parallel the continuing addition of neurons inThe olfactory bulb, and these two concomitant phenomena may ensure structural stability and functional plasticity to the primate Olfactory system and temporal lobe.