Subunits of the Saccharomyces cerevisiae signal recognition particle required for its functional expression.

  title={Subunits of the Saccharomyces cerevisiae signal recognition particle required for its functional expression.},
  author={Jeremy D. Brown and Byron Hann and Katalin F Medzihradszky and Maho Niwa and Alma L. Burlingame and Peter J. Walter},
  journal={The EMBO journal},
  volume={13 18},
The signal recognition particle (SRP) is an evolutionarily conserved ribonucleoprotein (RNP) complex that functions in protein targeting to the endoplasmic reticulum (ER) membrane. Only two protein subunits of the SRP, Srp54p and Sec65p, and the RNA subunit, scR1, were previously known in the yeast Saccharomyces cerevisiae. Purification of yeast SRP by immunoaffinity chromatography revealed five additional proteins. Amino acid sequencing and cloning of the genes encoding four of these proteins… CONTINUE READING
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