Subunits of mitochondrial complex I exist as part of matrix- and membrane-associated subcomplexes in living cells.

@article{Dieteren2008SubunitsOM,
  title={Subunits of mitochondrial complex I exist as part of matrix- and membrane-associated subcomplexes in living cells.},
  author={Cindy E J Dieteren and Peter H G M Willems and Rutger O. Vogel and Herman G. P. Swarts and Jack Fransen and Ronald Roepman and Gijs Crienen and Jan A M Smeitink and Leo G. J. Nijtmans and Werner J. H. Koopman},
  journal={The Journal of biological chemistry},
  year={2008},
  volume={283 50},
  pages={34753-61}
}
Mitochondrial complex I (CI) is a large assembly of 45 different subunits, and defects in its biogenesis are the most frequent cause of mitochondrial disorders. In vitro evidence suggests a stepwise assembly process involving pre-assembled modules. However, whether these modules also exist in vivo is as yet unresolved. To answer this question, we here… CONTINUE READING