Subunits Stimulate p 114 RhoGEF , a Guanine Nucleotide Exchange Factor for RhoA and Rac 1 Regulation of Cell Shape and Reactive Oxygen Species Production

@inproceedings{Niu2003SubunitsSP,
  title={Subunits Stimulate p 114 RhoGEF , a Guanine Nucleotide Exchange Factor for RhoA and Rac 1 Regulation of Cell Shape and Reactive Oxygen Species Production},
  author={Jiaxin Niu and Jasmina Profirovic and Haiyun Pan and Rita Vaiskunaite and Tatyana A. Voyno-Yasenetskaya},
  year={2003}
}
Rho GTPases integrate the intracellular signaling in a wide range of cellular processes. Activation of these G proteins is tightly controlled by a number of guanine nucleotide exchange factors (GEFs). In this study, we addressed the functional role of the recently identified p114RhoGEF in in vivo experiments. Activation of endogenous G protein–coupled receptors with lysophosphatidic acid resulted in activation of a transcription factor, serum response element (SRE), that was enhanced by… CONTINUE READING
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