Subunit-subunit interactions are critical for proton sensitivity of ROMK: evidence in support of an intermolecular gating mechanism.

@article{Leng2006SubunitsubunitIA,
  title={Subunit-subunit interactions are critical for proton sensitivity of ROMK: evidence in support of an intermolecular gating mechanism.},
  author={Qiang Leng and Gordon G Macgregor and Ke Dong and Gerhard Giebisch and Steven C. Hebert},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2006},
  volume={103 6},
  pages={1982-7}
}
The tetrameric K channel ROMK provides an important pathway for K secretion by the mammalian kidney, and the gating of this channel is highly sensitive to changes in cytosolic pH. Although charge-charge interactions have been implicated in pH sensing by this K channel tetramer, the molecular mechanism linking pH sensing and the gating of ion channels is poorly understood. The x-ray crystal structure KirBac1.1, a prokaryotic ortholog of ROMK, has suggested that channel gating involves… CONTINUE READING

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Ph Ys Io Lo G Y

M. Casamassima, M. C. D’Adamo, M. Pessia, S. J. Tucker
J. Biol • 2002

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