Subunit structure of the erythropoietin receptor.

  title={Subunit structure of the erythropoietin receptor.},
  author={Peter McCaffery and John K. Fraser and Feng-ying Kimi Lin and Michael V Berridge},
  journal={The Journal of biological chemistry},
  volume={264 18},
Chemical cross-linking of the red blood cell hormone, erythropoietin (Epo), to its receptor on erythroid cells has revealed the presence of two proteins closely associated with Epo, but the relationship between these two proteins is controversial. Using the cross-linking reagents disuccinimidyl suberate and dithiobissuccinimidyl propionate, we show that 125I-Epo can be specifically conjugated in a complex of 224kDa using mouse fetal liver cells, bone marrow cells, and Friend virus-induced… CONTINUE READING


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