Subunit-specific role for the amino-terminal domain of AMPA receptors in synaptic targeting.

@article{DazAlonso2017SubunitspecificRF,
  title={Subunit-specific role for the amino-terminal domain of AMPA receptors in synaptic targeting.},
  author={Javier D{\'i}az-Alonso and Yujiao Jennifer Sun and Adam J. Granger and Jonathan M Levy and Sabine M. Blankenship and Roger A Nicoll},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2017},
  volume={114 27},
  pages={
          7136-7141
        }
}
The amino-terminal domain (ATD) of AMPA receptors (AMPARs) accounts for approximately 50% of the protein, yet its functional role, if any, remains a mystery. We have discovered that the translocation of surface GluA1, but not GluA2, AMPAR subunits to the synapse requires the ATD. GluA1A2 heteromers in which the ATD of GluA1 is absent fail to translocate, establishing a critical role of the ATD of GluA1. Inserting GFP into the ATD interferes with the constitutive synaptic trafficking of GluA1… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 1 time over the past 90 days. VIEW TWEETS

References

Publications referenced by this paper.
Showing 1-10 of 40 references

Similar Papers

Loading similar papers…