Subunit-specific regulation of NMDA receptor endocytosis.

  title={Subunit-specific regulation of NMDA receptor endocytosis.},
  author={Gabriela Lavezzari and J. Stuart McCallum and Colleen M. Dewey and Katherine W. Roche},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  volume={24 28},
At excitatory synapses, both NMDA and AMPA receptors are localized to the postsynaptic density (PSD). However, unlike AMPA receptors, synaptic NMDA receptors are stable components of the PSD. Even so, surface-expressed NMDA receptors undergo endocytosis, which is more robust early in development and declines during synaptic development. We investigated the subunit-specific contributions to NMDA receptor endocytosis, specifically defining the endocytic motifs and endocytic pathways preferred by… CONTINUE READING
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