Subunit recombinant vaccine protects against monkeypox.

  title={Subunit recombinant vaccine protects against monkeypox.},
  author={Jean-Michel Heraud and Yvette Y Edghill-Smith and Victor Ayala and Irene Kalisz and Janie Parrino and Vaniambadi S. Kalyanaraman and Jody Manischewitz and Lisa R. King and Anna Hryniewicz and Christopher J. Trindade and Meredith Hassett and W M Tsai and David J Venzon and Aysegul Nalca and Monica Vaccari and Peter M Silvera and Mike Bray and Barney S. Graham and H. Golding and Jay W Hooper and Genoveffa Franchini},
  journal={Journal of immunology},
  volume={177 4},
The smallpox vaccine Dryvax, a live vaccinia virus (VACV), protects against smallpox and monkeypox, but is contraindicated in immunocompromised individuals. Because Abs to VACV mediate protection, a live virus vaccine could be substituted by a safe subunit protein-based vaccine able to induce a protective Ab response. We immunized rhesus macaques with plasmid DNA encoding the monkeypox orthologs of the VACV L1R, A27L, A33R, and B5R proteins by the intradermal and i.m. routes, either alone or in… CONTINUE READING


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