Subunit positional effects revealed by novel heteromeric inwardly rectifying K+ channels.

@article{Pessia1996SubunitPE,
  title={Subunit positional effects revealed by novel heteromeric inwardly rectifying K+ channels.},
  author={Mauro Pessia and Steven Jay Tucker and K Lee and Chris T. Bond and John P Adelman},
  journal={The EMBO journal},
  year={1996},
  volume={15 12},
  pages={2980-7}
}
Kir 4.1 is an inward rectifier potassium channel subunit isolated from rat brain which forms homomeric channels when expressed in Xenopus oocytes; Kir 5.1 is a structurally related subunit which does not. Co-injection of mRNAs encoding Kir 4.1 and Kir 5.1 resulted in potassium currents that (i) were much larger than those seen from expression of Kir 4.1 alone, (ii) increased rather than decreased during several seconds at strongly negative potentials and (iii) had an underlying unitary… CONTINUE READING

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