Subunit interactions in the assembly of neuronal Kir3.0 inwardly rectifying K+ channels.

  title={Subunit interactions in the assembly of neuronal Kir3.0 inwardly rectifying K+ channels.},
  author={Frank D{\"o}ring and Erhard Wischmeyer and Alexander Spauschus and Achim Thomzig and R{\"u}diger W Veh and Andreas Karschin},
  journal={Molecular and cellular neurosciences},
  volume={9 3},
Cardiac G protein-activated Kir (GIRK) channels may assemble as heterotetrameric polypeptides from two subunits, Kir3.1 and Kir3.4. For a functional comparison with native channels in the CNS we investigated all possible combinations of heteromeric channel formation from brain Kir3.1, Kir3.2, Kir3.3, and Kir3.4 subunits in mRNA-injected Xenopus oocytes. Analysis of macroscopic current amplitudes and channel gating kinetics indicated that individual subunits or combinations of Kir3.2, Kir3.3… CONTINUE READING

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