Subunit change in cytochrome c oxidase: identification of the oxygen switch in Dictyostelium.

  title={Subunit change in cytochrome c oxidase: identification of the oxygen switch in Dictyostelium.},
  author={Ryan Bisson and Silvia Vettore and E Aratri and Doriana Sandon{\`a}},
  journal={The EMBO journal},
  volume={16 4},
Cytochrome c oxidase (COX) has a complex modular structure in eukaryotes. Depending on growth conditions, interchangeable isoforms of selected subunits are synthesized and combined to the evolutionarily conserved catalytic core of the enzyme. In Dictyostelium this structural make-up is regulated by oxygen and involves two forms of the smallest subunit, termed VIIe and VIIs. Here we show that, in spite of a considerable sequence divergency, they are encoded by adjacent genes, linked 'tail to… CONTINUE READING
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