Subunit assembly of N-methyl-d-aspartate receptors analyzed by fluorescence resonance energy transfer.

@article{Qiu2005SubunitAO,
  title={Subunit assembly of N-methyl-d-aspartate receptors analyzed by fluorescence resonance energy transfer.},
  author={Shuang Qiu and Yu-Lin Hua and Fan Yang and Yi-Zhang Chen and Jianhong Luo},
  journal={The Journal of biological chemistry},
  year={2005},
  volume={280 26},
  pages={24923-30}
}
N-methyl-d-aspartate (NMDA) receptors play major roles in synaptic transmission and plasticity, as well as excitotoxicity. NMDA receptors are thought to be tetrameric complexes mainly composed of NMDA receptor (NR)1 and NR2 subunits. The NR1 subunits are required for the formation of functional NMDA receptor channels, whereas the NR2 subunits modify channel properties. Biochemical and functional studies indicate that subunits making up NMDA receptors are organized into a dimer of dimers, and… CONTINUE READING