Subunit arrangement of gamma-aminobutyric acid type A receptors.

  title={Subunit arrangement of gamma-aminobutyric acid type A receptors.},
  author={Sabine W. Baumann and Roland Baur and Erwin Sigel},
  journal={The Journal of biological chemistry},
  volume={276 39},
The GABA(A) receptors are ligand-gated chloride channels. The subunit stoichiometry of the receptors is controversial; four, five, or six subunits per receptor molecule have been proposed for alphabeta receptors, whereas alphabetagamma receptors are assumed to be pentamers. In this study, alpha-beta and beta-alpha tandem cDNAs from the alpha1 and beta2 subunits of the GABA(A) receptor were constructed. We determined the minimal length of the linker that is required between the two subunits for… CONTINUE READING