• DOI:10.1038/nature04089
Corpus ID: 4400777

Subunit arrangement and function in NMDA receptors

@article{Furukawa2005SubunitAA,
  title={Subunit arrangement and function in NMDA receptors},
  author={Hiro Furukawa and S. Singh and R. Mancusso and E. Gouaux},
  journal={Nature},
  year={2005},
  volume={438},
  pages={185-192}
}

• Hiro Furukawa, S. Singh, +1 author E. Gouaux
• Published 2005
• Chemistry, Medicine
• Nature

Excitatory neurotransmission mediated by NMDA (N-methyl-d-aspartate) receptors is fundamental to the physiology of the mammalian central nervous system. These receptors are heteromeric ion channels that for activation require binding of glycine and glutamate to the NR1 and NR2 subunits, respectively. NMDA receptor function is characterized by slow channel opening and deactivation, and the resulting influx of cations initiates signal transduction cascades that are crucial to higher functions… Expand

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