Subunit approach to evaluation of the immune protective potential of leptospiral antigens.


Leptospirosis is the most widespread zoonosis in the world. Current vaccines are based on whole-cell preparations that cause severe side effects and do not induce satisfactory immunity. In light of the leptospiral genome sequences recently made available, several studies aimed at identification of protective recombinant immunogens have been performed… (More)
DOI: 10.1128/CVI.05297-11


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