Subtyping sub-Saharan esophageal squamous cell carcinoma by comprehensive molecular analysis.

  title={Subtyping sub-Saharan esophageal squamous cell carcinoma by comprehensive molecular analysis.},
  author={Wenjin Liu and Jeff M. Snell and William R Jeck and Katherine A Hoadley and Matthew D Wilkerson and Joel S. Parker and Nirali Patel and Yohannie Billy Mlombe and Gift Mulima and N. George Liomba and Lindsey L. Wolf and Carol G. Shores and Satish Gopal and Norman E Sharpless},
  journal={JCI insight},
  volume={1 16},
Esophageal squamous cell carcinoma (ESCC) is endemic in regions of sub-Saharan Africa (SSA), where it is the third most common cancer. Here, we describe whole-exome tumor/normal sequencing and RNA transcriptomic analysis of 59 patients with ESCC in Malawi. We observed similar genetic aberrations as reported in Asian and North American cohorts, including mutations of TP53, CDKN2A, NFE2L2, CHEK2, NOTCH1, FAT1, and FBXW7. Analyses for nonhuman sequences did not reveal evidence for infection with… CONTINUE READING
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