Subtypes of the somatostatin receptor assemble as functional homo- and heterodimers.

@article{Rocheville2000SubtypesOT,
  title={Subtypes of the somatostatin receptor assemble as functional homo- and heterodimers.},
  author={Magalie Rocheville and Daniela C Lange and Ujendra Kumar and R Kanth Sasi and Ramesh C. Patel and Yogesh C. Patel},
  journal={The Journal of biological chemistry},
  year={2000},
  volume={275 11},
  pages={7862-9}
}
The existence of receptor dimers has been proposed for several G protein-coupled receptors. However, the question of whether G protein-coupled receptor dimers are necessary for activating or modulating normal receptor function is unclear. We address this question with somatostatin receptors (SSTRs) of which there are five distinct subtypes. By using transfected mutant and wild type receptors, as well as endogenous receptors, we provide pharmacological, biochemical, and physical evidence, based… CONTINUE READING