Subtypes of primary colorectal tumors correlate with response to targeted treatment in colorectal cell lines

@inproceedings{Schlicker2012SubtypesOP,
  title={Subtypes of primary colorectal tumors correlate with response to targeted treatment in colorectal cell lines},
  author={A Christine Schlicker and Garry J Beran and Christine M. Chresta and Gael McWalter and Alison Pritchard and Susie L. Weston and Sarah K. Runswick and Sara Davenport and Kerry Heathcote and Denis Alferez Castro and George Orphanides and Tim French and L. F. A. Wessels},
  booktitle={BMC Medical Genomics},
  year={2012}
}
Colorectal cancer (CRC) is a heterogeneous and biologically poorly understood disease. To tailor CRC treatment, it is essential to first model this heterogeneity by defining subtypes of patients with homogeneous biological and clinical characteristics and second match these subtypes to cell lines for which extensive pharmacological data is available, thus linking targeted therapies to patients most likely to respond to treatment. We applied a new unsupervised, iterative approach to stratify CRC… CONTINUE READING
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