Subtypes of physical frailty: Latent class analysis and associations with clinical characteristics and outcomes

@article{Liu2017SubtypesOP,
  title={Subtypes of physical frailty: Latent class analysis and associations with clinical characteristics and outcomes},
  author={Li-Kuo Liu and Chao-Yu Guo and Wei‐Ju Lee and LiangYu Chen and An-Chun Hwang and Ming-Hsien Lin and Li-Ning Peng and Liang‐Kung Chen and K Y Liang},
  journal={Scientific Reports},
  year={2017},
  volume={7}
}
Frailty is a well-recognized geriatric syndrome with various definitions and conceptual frameworks. This study aimed to use latent class analysis to discover potential subtypes of pre-frail and frail older people. Data from the I-Lan Longitudinal Aging Study (ILAS), a community-based cohort study was used for analysis. Latent class analysis was applied to characterize classes or subgroups with different frailty phenotypes among ILAS participants targeting older adults aged 65 and above, capable… 
Frailty Status Typologies in Spanish Older Population: Associations with Successful Aging
TLDR
Four different patterns of frailty attributes were revealed and further offered evidence on individuals’ differential status of health regarding distinct frailty conditions as compared to other frailty subgroups.
The frail older person does not exist: development of frailty profiles with latent class analysis
TLDR
The research provides an empirical base for meaningful frailty profiles based on the physical, psychological, social and cognitive domains of functioning and the severity of the problems within these domains.
Different Cognitive Frailty Models and Health- and Cognitive-related Outcomes in Older Age: From Epidemiology to Prevention
TLDR
The framework for the definition, different models, and the current epidemiology of Cognitive frailty are reviewed, also describing neurobiological mechanisms, and exploring the possible prevention of the cognitive frailty progression are reviewed.
Physical frailty and cognitive impairment in older nursing home residents: a latent class analysis
TLDR
Findings indicate the heterogeneous presentations of physical frailty in older nursing home residents and additional evidence on the interrelationship betweenPhysical frailty and cognitive impairment.
Heterogeneous Influence of Frailty Phenotypes in Age-Related Hearing Loss and Tinnitus in Chinese Older Adults: An Explorative Study
TLDR
Frailty phenotypes have divergent association with hearing loss (HL) and tinnitus, and patients with physical frailty (mobility frailty) or who are robust were found to have lower probability of developing severe HL andTinnitus than those with only cognitive decline, or CF.
Cognitive frailty predicting all-cause mortality among community-living older adults in Taiwan: A 4-year nationwide population-based cohort study
TLDR
Dynapenia and cognitive impairment synergistically contribute to the mortality risk for the participants in this study and further study is needed to explore the underlying pathophysiology and the reversibility of CF.
Development of frailty subtypes and their associated risk factors among the community-dwelling elderly population
TLDR
The findings confirm the heterogeneity of frailty and suggest that different frail elderly individuals need more targeted care interventions.
Portals to frailty? Data-driven analyses detect early frailty profiles
TLDR
A data-driven approach to early frailty assessment detected differentiable profiles that may be characterized as morbidity-intensive portals into broader and chronic frailty.
Cluster of factors associated with physical frailty in community-dwelling elderly people
TLDR
The development of actions that encourage a healthier lifestyle to favor the prevention and treatment of physical frailty, as well as to increase health literacy and knowledge, may reduce the problems related to this condition in older adults, mainly thinking about the next generations.
...
...

References

SHOWING 1-10 OF 82 REFERENCES
Prevalence of frailty phenotypes and risk of mortality in a community-dwelling elderly cohort.
TLDR
Three different disability-free frailty phenotypes were differentially related to the socio-demographical characteristics of sex, age and marital status and independently predicted risk of mortality.
Initial manifestations of frailty criteria and the development of frailty phenotype in the Women's Health and Aging Study II.
TLDR
It is suggested that weakness may serve as a warning sign of increasing vulnerability in early frailty development, and weight loss and exhaustion may help to identify women most at risk for rapid adverse progression.
Cognitive impairment and low physical activity are the components of frailty more strongly associated with disability
TLDR
Better understanding the independent contribution of each frailty subdimension to the different adverse-health outcomes may help to provide a more adequate management of frail elderly.
Frailty in older adults: evidence for a phenotype.
TLDR
This study provides a potential standardized definition for frailty in community-dwelling older adults and offers concurrent and predictive validity for the definition, and finds that there is an intermediate stage identifying those at high risk of frailty.
Phenotype of frailty: characterization in the women's health and aging studies.
TLDR
The frailty definition developed in the CHS is applicable across diverse population samples and identifies a profile of high risk of multiple adverse outcomes and is consistent with the widely held theory that conceptualizes frailty as a syndrome.
Association of Frailty and Cardiometabolic Risk Among Community-Dwelling Middle-Aged and Older People: Results from the I-Lan Longitudinal Aging Study.
TLDR
In this study, abdominal obesity, insulin resistance, and inflammation were significantly associated with frailty, and the effect was independent of functional measurement and decline of skeletal muscle mass.
Cognitive Frailty and Its Association with All-Cause Mortality Among Community-Dwelling Older Adults in Taiwan: Results from I-Lan Longitudinal Aging Study.
TLDR
The association between cognitive frailty and all-cause mortality among community-living older adults and the I-Lan Longitudinal Aging Study (ILAS) was evaluated to explore the pathophysiology and reversibility of Cognitive frailty.
Frailty Syndrome: A Transitional State in a Dynamic Process
TLDR
A better understanding of these clinical changes and their underlying mechanisms may confirm the impression held by many geriatricians that increasing frailty is distinguishable from ageing and in consequence is potentially reversible.
...
...