Subtypes of beta-adrenergic receptors in rat cerebral microvessels.

@article{Kobayashi1981SubtypesOB,
  title={Subtypes of beta-adrenergic receptors in rat cerebral microvessels.},
  author={Hideyuki Kobayashi and T. Maoret and Margherita Ferrante and Pier Franco Spano and Marco Trabucchi},
  journal={Brain research},
  year={1981},
  volume={220 1},
  pages={194-8}
}
The 125I-labeled iodohydroxybenzylpindolol (IHYP) binding to beta-receptors on brain micro-vessels is inhibited by isoproterenol, epinephrine and norepinephrine, with Ki values of 2 X 10(-7) M, 2.5 X 10(-6) M and 1.2 X 10(-5) M, respectively. A modified Scatchard analysis of the inhibitory effects of practolol, metroprolol and zinterol on IHYP binding has shown that the proportion of beta 2-receptors in our preparation is about 80% of the total beta-adrenergic receptor population. Our data… CONTINUE READING