Subtypes of NMDA receptors in new-born rat hippocampal granule cells.

@article{PiaCrespo2002SubtypesON,
  title={Subtypes of NMDA receptors in new-born rat hippocampal granule cells.},
  author={Juan C Pi{\~n}a-Crespo and Alasdair J Gibb},
  journal={The Journal of physiology},
  year={2002},
  volume={541 Pt 1},
  pages={41-64}
}
To investigate the properties of NMDA receptors expressed in new-born rat hippocampal granule cells, recordings were made of single-channel currents produced by application of glutamate or NMDA to outside-out membrane patches. Outside-out patches displayed two distinct patterns of single-channel activity. In some patches only high conductance single-channel activity composed of 42 and 50 pS currents was observed while in others both high (42 and 50 pS) and low (17 and 33 pS) conductance single… CONTINUE READING