Subtype specific roles of serotonin receptors in the spine formation of cortical neurons in vitro

  title={Subtype specific roles of serotonin receptors in the spine formation of cortical neurons in vitro
  author={Hiroyuki Yoshida and Chisako Kanamaru and Akiko Ohtani and Fei Li and Kouji Senzaki and Takashi Shiga},
  journal={Neuroscience Research},
Activation of the neurokinin 3 receptor promotes filopodia growth and sprouting in rat embryonic hypothalamic cells
The results suggest that the ligand‐induced activation of NK3R affects early developmental processes by initiating filopodia formation that are a prerequisite for neuritogenesis.
The role of serotonin 5-HT2A receptors in memory and cognition
It is concluded that the development of selective 5-HT2AR modulators to target distinct signaling pathways and neural circuits represents a new possibility for treating emotional, neuropsychiatric, and neurodegenerative disorders.
The roles of serotonin in cell adhesion and migration, and cytoskeletal remodeling
The role of serotonin in psychiatric illness, as well as in the positive and negative effects of neuropsychiatric drugs through cell-related adhesion can be of great significance, is explored.
Serotonin 5-HT Receptor Currents in the Healthy Rodent Prefrontal Cortex and in a Model of Affective Disorders
The objectives of this thesis were to delve deeper into the 5-HT receptor subtypes that modulate the prefrontal cortex in the healthy control rodents and to examine how this modulation was disrupted in a rodent model of affective disorders.
Fluoxetine exposure throughout neurodevelopment differentially influences basilar dendritic morphology in the motor and prefrontal cortices
The findings underscore that the developing brain, specifically the projection cortex, is vulnerable to 5HT system perturbation, which may be related to later behavioral disruptions.
Effects of antipsychotic drugs on neurites relevant to schizophrenia treatment
A review revealed that high doses and chronic administration of antipsychotic drugs may cause some loss of neurites, synaptic spines, or synapsis in the cortical structures, and confounding effects causing neurite deficits may include elevated inflammatory cytokines and antipsychotics drug‐induced metabolic side effects in patients on chronic antipsychosis therapy.
Serotonin in fear conditioning processes
  • E. Bauer
  • Psychology, Biology
    Behavioural Brain Research
  • 2015


Rapid modulation of spine morphology by the 5-HT2A serotonin receptor through kalirin-7 signaling
It is shown that peptide interference that prevents the localization of kalirin-7 to the postsynaptic density disrupts DOI-induced PAK phosphorylation and spine morphogenesis, suggesting a potential role for serotonin signaling in modulating spine morphology and kal Kirin-7's function at cortical synapses.
Embryonic depletion of serotonin affects cortical development
It was found that E12–17 PCPA treatment altered the maturation of pyramidal neurons of layers’III and V of the somatosensory cortex, with these cells displaying reduced dendritic arborization and complexity.
Cellular and subcellular distribution of the serotonin 5‐HT2A receptor in the central nervous system of adult rat
Following immunoperoxidase or silver‐intensified immunogold labeling, neuronal, somatodendritic, and/or axonal immunoreactivity was detected in numerous brain regions, including all those in which ligand binding sites and 5‐HT2A mRNA had previously been reported.