Subtype specific roles of serotonin receptors in the spine formation of cortical neurons in vitro

@article{Yoshida2011SubtypeSR,
  title={Subtype specific roles of serotonin receptors in the spine formation of cortical neurons in vitro
},
  author={Hiroyuki Yoshida and Chisako Kanamaru and Akiko Ohtani and Fei Li and Kouji Senzaki and Takashi Shiga},
  journal={Neuroscience Research},
  year={2011},
  volume={71},
  pages={311-314}
}
Dendritic spines are postsynaptic structures which are formed from filopodia. We examined roles of serotonin (5-HT) receptors in the spine formation. Embryonic rat cortical neurons were cultured for 10 or 14 days and treated by 5-HT receptor agonists for 24 h. At 11 days in vitro, 5-HT(1A) agonist increased filopodia density, whereas 5-HT(2A/2C) agonist increased the density of puncta and spines. At 15 days in vitro, 5-HT(1A) agonist decreased the density of puncta and spines, whereas 5-HT(2A… Expand
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