Subtype-specific changes in 5-HT receptor-mediated modulation of C fibre-evoked spinal field potentials are triggered by peripheral nerve injury

@article{Aira2010SubtypespecificCI,
  title={Subtype-specific changes in 5-HT receptor-mediated modulation of C fibre-evoked spinal field potentials are triggered by peripheral nerve injury},
  author={Zigor Aira and Itsaso Buesa and M{\'o}nika Salgueiro and Juan Bilbao and Luciano Aguilera and Manfred Zimmermann and Jon Jatsu Azkue},
  journal={Neuroscience},
  year={2010},
  volume={168},
  pages={831-841}
}

Figures from this paper

Time-Dependent Cross Talk between Spinal Serotonin 5-HT2A Receptor and mGluR1 Subserves Spinal Hyperexcitability and Neuropathic Pain after Nerve Injury

A role for 5-HT2AR in hyperexcitation and pain after nerve injury is emphasized and mGluR1 upregulation is supported as a novel feedforward activation mechanism contributing to 5- HT2AR-mediated facilitation.

Spinal 5-HT3 receptors mediate descending facilitation and contribute to behavioral hypersensitivity via a reciprocal neuron-glial signaling cascade

These findings offer new insights into the cellular and molecular mechanisms at the spinal level responsible for descending 5-HT-mediated pain facilitation during the development of persistent pain after tissue and nerve injury.

Spinal 5-HT3 Receptor Activation Induces Behavioral Hypersensitivity via a Neuronal-Glial-Neuronal Signaling Cascade

Findings offer new insights into the cellular and molecular mechanisms at the spinal level responsible for descending 5-HT-mediated pain facilitation during the development of persistent pain after tissue and nerve injury.
...

References

SHOWING 1-10 OF 113 REFERENCES

Spinal 5-HT3 receptor-mediated antinociception: possible release of GABA

5-HT via an action at 5-HT3 receptors may evoked release of GABA, which may in turn inhibit nociceptive transmission at a site postsynaptic to terminals of primary afferent fibers, and understanding it may enable the development of new nonopioid, nonaddictive analgesics.

Roles of 5-Hydroxytryptamine (5-HT) Receptor Subtypes in the Inhibitory Effects of 5-HT on C-Fiber Responses of Spinal Wide Dynamic Range Neurons in Rats

Results suggest that, under basal conditions, there is no tonic serotonergic inhibition on the C-responses of dorsal horn neurons, and multiple 5-HT receptor subtypes including 1B, 2A, and 1B-indole-3-carboxylate had no effect on their own.

Enhanced Evoked Excitatory Transmitter Release in Experimental Neuropathy Requires Descending Facilitation

Nerve injury-induced afferent discharge is thought to elicit spinal sensitization and consequent abnormal pain. Experimental neuropathic pain, however, also depends on central changes, including

Serotonergic modulation of spinal sensory circuits.

A subset of studies that used electrophysiological techniques to study the mechanisms of action as well as the receptors mediating the spinal effects of serotonin, finding that 5-HT triggers depressant effects on synaptic transmission limiting the release of neurotransmitters from afferent terminals or the responsiveness of NMDA receptors located in dorsal horn neurones are reviewed.
...