Subtype selectivity of the positive allosteric action of alcuronium at cloned M1-M5 muscarinic acetylcholine receptors.

@article{Jakubk1995SubtypeSO,
  title={Subtype selectivity of the positive allosteric action of alcuronium at cloned M1-M5 muscarinic acetylcholine receptors.},
  author={Jan Jakub{\'i}k and Lucie Ba{\vc}{\'a}kov{\'a} and Esam E. El-Fakahany and Stanislav Tu{\vc}ek},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1995},
  volume={274 3},
  pages={1077-83}
}
The neuromuscular blocking drug alcuronium was found earlier to increase the affinity of muscarinic receptors for methyl-N-scopolamine (NMS). This effect could be observed in some but not in other tissues. Subtype selectivity of the positive allosteric action of alcuronium was now investigated in radioligand binding experiments in Chinese hamster ovary (CHO) cells stably transfected with the genes encoding the M1-M5 subtypes of muscarinic receptors. Alcuronium had a particularly high affinity… CONTINUE READING

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