Subtype selective kainic acid receptor agonists: Discovery and approaches to rational design

@article{Bunch2009SubtypeSK,
  title={Subtype selective kainic acid receptor agonists: Discovery and approaches to rational design},
  author={Lennart Bunch and Povl Krogsgaard‐Larsen},
  journal={Medicinal Research Reviews},
  year={2009},
  volume={29}
}
(S)‐Glutamic acid (Glu) is the major excitatory neurotransmitter in the mammalian central nervous system, activating the plethora of glutamate receptors (GluRs). In broad lines, the GluRs are divided into two major classes: the ionotropic Glu receptors (iGluRs) and the metabotropic Glu receptors (mGluRs). Within the iGluRs, five subtypes (KA1, KA2, iGluR5‐7) show high affinity and express full agonist activity upon binding of the naturally occurring amino acid kainic acid (KA). Thus these… 
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