Subtype-selective corticotropin-releasing factor receptor agonists exert contrasting, but not opposite, effects on anxiety-related behavior in rats.

@article{Zhao2007SubtypeselectiveCF,
  title={Subtype-selective corticotropin-releasing factor receptor agonists exert contrasting, but not opposite, effects on anxiety-related behavior in rats.},
  author={Yuanxiang Zhao and Glenn R Valdez and Eva M. Fekete and Jean E F Rivier and Wylie W. Vale and Kenner C. Rice and Friedbert Weiss and Eric Zorrilla},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2007},
  volume={323 3},
  pages={846-54}
}
The corticotropin-releasing factor (CRF) system mediates stress responses. Extrahypothalamic CRF1 receptor activation has anxiogenic-like properties, but anxiety-related functions of CRF2 receptors remain unclear. The present study determined the effects of intracerebroventricular administration of a CRF2 agonist, urocortin 3, on behavior of male Wistar rats in the shock-probe, social interaction, and defensive withdrawal tests of anxiety-like behavior. Equimolar doses of stressin1-A, a novel… CONTINUE READING

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