Subtype-selective conopeptides targeted to nicotinic receptors: Concerted discovery and biomedical applications.

@article{Olivera2008SubtypeselectiveCT,
  title={Subtype-selective conopeptides targeted to nicotinic receptors: Concerted discovery and biomedical applications.},
  author={Baldomero M Olivera and Maryka Quik and Michelle A. Vincler and John McIntosh},
  journal={Channels},
  year={2008},
  volume={2 2},
  pages={143-52}
}
Conus peptides that are selectively targeted to different molecular isoforms of nicotinic acetylcholine receptors (nAChRs) have been identified and characterized; several have recently been shown to have significant biomedical potential. An emerging strategy for the discovery from animal biodiversity of subtype-specific ligands for ion channel families is described in this review. Characterization of the gene family encoding a set of related ligands is required for discovery using a molecular… CONTINUE READING

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