Subtype-selective antagonism of N-methyl-D-aspartate receptors by felbamate: insights into the mechanism of action.

@article{Kleckner1999SubtypeselectiveAO,
  title={Subtype-selective antagonism of N-methyl-D-aspartate receptors by felbamate: insights into the mechanism of action.},
  author={Nancy Way Kleckner and J C Glazewski and Chinchi C. Chen and Tammy D. Moscrip},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1999},
  volume={289 2},
  pages={
          886-94
        }
}
Felbamate is an anticonvulsant used in the treatment of seizures associated with Lennox-Gastaut syndrome and complex partial seizures that are refractory to other medications. Its unique clinical profile is thought to be due to an interaction with N-methyl-D-aspartate (NMDA) receptors, resulting in decreased excitatory amino acid neurotransmission. To further characterize the interaction between felbamate and NMDA receptors, recombinant receptors expressed in Xenopus oocytes were used to… CONTINUE READING

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