Subtype selective NMDA receptor antagonists induce recovery of synapses lost following exposure to HIV-1 Tat.

@article{Shin2012SubtypeSN,
  title={Subtype selective NMDA receptor antagonists induce recovery of synapses lost following exposure to HIV-1 Tat.},
  author={Angela H. Shin and Hyun Joon Kim and Stanley A Thayer},
  journal={British journal of pharmacology},
  year={2012},
  volume={166 3},
  pages={1002-17}
}
BACKGROUND AND PURPOSE Neurocognitive disorders afflict approximately 20% of HIV-infected patients. HIV-1-infected cells in the brain shed viral proteins such as transactivator of transcription (Tat). Tat elicits cell death and synapse loss via processes initiated by NMDA receptor activation but mediated by separate downstream signalling pathways. Subunit… CONTINUE READING