Subtype-selective GABAA receptor mimetics—novel antihyperalgesic agents?

@article{Zeilhofer2009SubtypeselectiveGR,
  title={Subtype-selective GABAA receptor mimetics—novel antihyperalgesic agents?},
  author={H. Zeilhofer and Robert Witschi and K. H{\"o}sl},
  journal={Journal of Molecular Medicine},
  year={2009},
  volume={87},
  pages={465-469}
}
Agonists at the benzodiazepine-binding site of ionotropic γ-aminobutyric acid (GABAA) receptors are in clinical use as hypnotics, anxiolytics, and anticonvulsants since the early 1960. Analgesic effects of classical benzodiazepines have occasionally been reported in certain subgroups of patients suffering from chronic pain or after spinal delivery through intrathecal catheters. However, these drugs are generally not considered as analgesics but should in fact be avoided in patients with chronic… Expand
Inhibition of carbonic anhydrase augments GABAA receptor-mediated analgesia via a spinal mechanism of action.
Ion channel blockers for the treatment of neuropathic pain.
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