Subtle conformational changes between CX3CR1 genetic variants as revealed by resonance energy transfer assays.

Abstract

The chemokine CX3CL1 is expressed as a membrane protein that forms a potent adhesive pair with its unique receptor CX3CR1. This receptor has 3 natural variants, V249-T280 (VT), I249-T280 (IT), and I249-M280 (IM), whose relative frequencies are significantly associated with the incidence of various inflammatory diseases. To assess the adhesive potency of… (More)
DOI: 10.1096/fj.10-156612

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