Subthreshold Na+-dependent theta-like rhythmicity in stellate cells of entorhinal cortex layer II

@article{Alonso1989SubthresholdNT,
  title={Subthreshold Na+-dependent theta-like rhythmicity in stellate cells of entorhinal cortex layer II},
  author={Angel A. Alonso and Rodolfo R. Llin{\'a}s},
  journal={Nature},
  year={1989},
  volume={342},
  pages={175-177}
}
THE oscillation of membrane potential in mammalian central neurons is of interest because it relates to the role of oscillations in brain function. It has been proposed that the entorhinal cortex (EC), particularly the stellate cells of layer II (ECIIscs), plays an important part in the genesis of the theta rhythm1–3. These neurons occupy a key position in the neocortex-hippocampus-neocortex circuit, a crucial crossroad in memory functions4,5. Neuronal oscillations typically rely on the… Expand
Properties and role of I(h) in the pacing of subthreshold oscillations in entorhinal cortex layer II neurons.
TLDR
Results indicated that the interplay between I(NaP) and I(h) can sustain persistent subthreshold oscillations in SCs, which are thought to be instrumental in implementing theta rhythmicity in the entorhinal-hippocampal network. Expand
Subthreshold membrane potential oscillations in neurons of deep layers of the entorhinal cortex
TLDR
It is concluded that voltage- and Na+-dependent subthreshold membrane potential oscillations are not only present in stellate cells of entorhinal cortex-layer II, but are also typical for neurons of the deep layers of the entorHinal cortex. Expand
Slow Voltage‐Dependent Inactivation of a Sustained Sodium Current in Stellate Cells of Rat Entorhinal Cortex Layer II
TLDR
A biophysical characterization of the INaP expressed by EC layer II stellate cells, which is likely to contribute to the generation of synchronized oscillations that represent a well-known feature of EC and hippocampus, and are believed to play an important role in learning and memory processes. Expand
Artificial Synaptic Conductances Reduce Subthreshold Oscillations and Periodic Firing in Stellate Cells of the Entorhinal Cortex
TLDR
The ability of stellate cells to generate theta oscillations in the presence of generic in vivo-like patterns of stimulation is investigated and suggests that subthreshold oscillations may contribute less to in vivo response properties than has been hypothesized. Expand
Muscarinic modulation of the oscillatory and repetitive firing properties of entorhinal cortex layer II neurons.
TLDR
Investigation of intracellular recording in an in vitro rat brain slice preparation shows the muscarinic modulation of the electroresponsive properties of the two distinct classes of medial EC layer II projection neurons, the stellate cells (SCs) and non-SCs, and indicates an important role for the cholinergic system in tuning the oscillatory dynamics of entorhinal neurons. Expand
Persistent sodium channel activity mediates subthreshold membrane potential oscillations and low-threshold spikes in rat entorhinal cortex layer V neurons
TLDR
The presence of a persistent sodium current in entorhinal cortex layer V cells can cause the generation of oscillatory behavior, bursting activity and sustained discharge but, under pathological situations, may also contribute to epileptogenesis and neurodegeneration. Expand
Oscillatory Activity in Entorhinal Neurons and Circuits: Mechanisms and Function
TLDR
It is proposed that the oscillatory properties of layer II and V neurons and local circuits are responsible for setting up the proper temporal dynamics for the coordination of the multiple sensory inputs that converge onto EC and thus help to generate sensory representations and memory encoding. Expand
Intrinsic Circuit Organization and Theta–Gamma Oscillation Dynamics in the Entorhinal Cortex of the Rat
TLDR
It is found that EC5 and EC2 principal neurons form large axonal networks mainly within their layers, interconnected by the more vertically organized axon trees of EC3 pyramidal cells, which may underlie their behaviorally distinct firing patterns in the waking animal. Expand
Properties of Entorhinal Cortex Projection Cells to the Hippocampal Formation
TLDR
There are multiple connections from the entorhinal cortex (EC) to the hippocampus that carry the information from the EC to the hippocampi that are dependent on GABAB‐, atropine‐, and naloxone‐sensitive components to display long‐lasting inhibitions. Expand
Gamma Oscillations Induced by Kainate Receptor Activation in the Entorhinal Cortex In Vitro
TLDR
It is shown that the medial entorhinal cortex (mEC) in isolation in vitro generates gamma frequency oscillations in response to kainate receptor agonists, which are similar to oscillations seen in the hippocampus. Expand
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