Subthreshold Concentrations of Melatonin and Galantamine Improves Pathological AD-Hallmarks in Hippocampal Organotypic Cultures

Abstract

Melatonin is a neurohormone whose levels are significantly reduced or absent in Alzheimer’s disease (AD) patients. In these patients, acetylcholinesterase inhibitors (AChEI) are the major drug class used for their treatment; however, they present unwanted cholinergic side effects and have provided limited efficacy in clinic. Because combination therapy is… (More)
DOI: 10.1007/s12035-015-9272-5

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