Subthalamic nucleus stimulation reduces abnormal motor cortical overactivity in Parkinson disease.

@article{Payoux2004SubthalamicNS,
  title={Subthalamic nucleus stimulation reduces abnormal motor cortical overactivity in Parkinson disease.},
  author={Pierre Payoux and Philippe Remy and Philipe Damier and Malika Miloudi and Isabelle Loubinoux and Bernard Pidoux and V{\'e}ronique Gaura and Olivier Rascol and Yves Samson and Yves Agid},
  journal={Archives of neurology},
  year={2004},
  volume={61 8},
  pages={
          1307-13
        }
}
BACKGROUND Based on the basal ganglia model, it has been hypothesized that the efficacy of high-frequency stimulation of the subthalamic nucleus (STN) against parkinsonian symptoms relies on the activation of cortical premotor regions. In previous positron emission tomography activation studies, STN high-frequency stimulation was associated with selective activation of midline premotor areas during hand movements but mainly reduced the regional cerebral blood flow in movement-related areas… CONTINUE READING
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