Subthalamic nucleus stimulation-induced regional blood flow responses correlate with improvement of motor signs in Parkinson disease.

@article{Karimi2008SubthalamicNS,
  title={Subthalamic nucleus stimulation-induced regional blood flow responses correlate with improvement of motor signs in Parkinson disease.},
  author={Morvarid K Karimi and Navid Golchin and Samer D Tabbal and Tamara Hershey and Tom O. Videen and J Wu and J W M Usche and Fredy J. Revilla and Johanna M. Hartlein and Angie R Wernle and Jonathan W. Mink and Joel S. Perlmutter},
  journal={Brain : a journal of neurology},
  year={2008},
  volume={131 Pt 10},
  pages={2710-9}
}
Deep brain stimulation of the subthalamic nucleus (STN DBS) improves motor symptoms in idiopathic Parkinson's disease, yet the mechanism of action remains unclear. Previous studies indicate that STN DBS increases regional cerebral blood flow (rCBF) in immediate downstream targets but does not reveal which brain regions may have functional changes associated with improved motor manifestations. We studied 48 patients with STN DBS who withheld medication overnight and underwent PET scans to… CONTINUE READING