Subthalamic deep brain stimulation at individualized frequencies for Parkinson disease

  title={Subthalamic deep brain stimulation at individualized frequencies for Parkinson disease},
  author={Eric W. Tsang and Clement Hamani and Elena Moro and Filomena Mazzella and Utpal Saha and A. M. Lozano and Mojgan Hodaie and Rosalind S. Chuang and Thomas D.L. Steeves and S.Y. Lim and Bogdan Neagu and R. Chen},
  pages={1930 - 1938}
Objectives: The oscillation model of Parkinson disease (PD) states that, in the subthalamic nucleus (STN), increased θ (4–10 Hz) and β (11–30 Hz) frequencies were associated with worsening whereas γ frequencies (31–100 Hz) were associated with improvement of motor symptoms. However, the peak STN frequency in each band varied widely from subject to subject. We hypothesized that STN deep brain stimulation (DBS) at individualized γ frequencies would improve whereas θ or β frequencies would worsen… 

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