Subsurface ablation of atherosclerotic plaque using ultrafast laser pulses.

Abstract

We perform subsurface ablation of atherosclerotic plaque using ultrafast pulses. Excised mouse aortas containing atherosclerotic plaque were ablated with ultrafast near-infrared (NIR) laser pulses. Optical coherence tomography (OCT) was used to observe the ablation result, while the physical damage was inspected in histological sections. We characterize the effects of incident pulse energy on surface damage, ablation hole size, and filament propagation. We find that it is possible to ablate plaque just below the surface without causing surface damage, which motivates further investigation of ultrafast ablation for subsurface atherosclerotic plaque removal.

DOI: 10.1364/BOE.6.002552

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Cite this paper

@article{Lanvin2015SubsurfaceAO, title={Subsurface ablation of atherosclerotic plaque using ultrafast laser pulses.}, author={Thomas Lanvin and Donald B. Conkey and Aur{\'e}lien Frobert and J{\'e}r{\'e}my Valentin and J J Goy and St{\'e}phane Cook and M A Giraud and Demetri Psaltis}, journal={Biomedical optics express}, year={2015}, volume={6 7}, pages={2552-61} }