Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development.

Abstract

Cytochrome P450 2C9 (CYP2C9) is one of the most abundant CYP enzymes in the human liver. CYP2C9 metabolizes more than 100 therapeutic drugs, including tolbutamide, glyburide, diclofenac, celecoxib, torasemide, phenytoin losartan, and S-warfarin). Some natural and herbal compounds are also metabolized by CYP2C9, probably leading to the formation of toxic… (More)

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@article{Zhou2009SubstratesII, title={Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development.}, author={Shu-Feng Zhou and Zhiwei Zhou and Li-ping Yang and Jian-Ping Cai}, journal={Current medicinal chemistry}, year={2009}, volume={16 27}, pages={3480-675} }