Substrate utilization and kinetics of surfactant metabolism in evolving bronchopulmonary dysplasia.

@article{Spence2005SubstrateUA,
  title={Substrate utilization and kinetics of surfactant metabolism in evolving bronchopulmonary dysplasia.},
  author={Kimberly L Spence and James C G Zozobrado and Bruce W. Patterson and Aaron Hamvas},
  journal={The Journal of pediatrics},
  year={2005},
  volume={147 4},
  pages={480-5}
}
OBJECTIVES To use stable isotopically labeled precursors of pulmonary surfactant phospholipids to measure precursor utilization and surfactant turnover in premature infants who required mechanical ventilation at birth, 2 weeks, and >4 weeks of age. STUDY DESIGN Infants of < or =28 weeks' gestation received simultaneous 24-hour intravenous infusions of [1,2,3,4-13C4] palmitate and [1-13C1] acetate at birth, 2 weeks, and > or =4 weeks of life. Disaturated phospholipids were extracted from… CONTINUE READING