Substrate uptake, phosphorus repression, and effect of seed culture on glycopeptide antibiotic production: process model development and experimental validation.

Abstract

Actinomycetes, the soil borne bacteria which exhibit filamentous growth, are known for their ability to produce a variety of secondary metabolites including antibiotics. Industrial scale production of such antibiotics is typically carried out in a multi-substrate medium where the product formation may experience catabolite repression by one or more of the… (More)
DOI: 10.1002/bit.22505

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