Substrate twinning activates the signal recognition particle and its receptor

@article{Egea2004SubstrateTA,
  title={Substrate twinning activates the signal recognition particle and its receptor},
  author={Pascal F. Egea and Shu-ou Shan and Johanna Napetschnig and David F Savage and Peter J. Walter and Robert Michael Stroud},
  journal={Nature},
  year={2004},
  volume={427},
  pages={215-221}
}
Signal sequences target proteins for secretion from cells or for integration into cell membranes. As nascent proteins emerge from the ribosome, signal sequences are recognized by the signal recognition particle (SRP), which subsequently associates with its receptor (SR). In this complex, the SRP and SR stimulate each other's GTPase activity, and GTP hydrolysis ensures unidirectional targeting of cargo through a translocation pore in the membrane. To define the mechanism of reciprocal activation… CONTINUE READING
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