Substrate twinning activates the signal recognition particle and its receptor

  title={Substrate twinning activates the signal recognition particle and its receptor},
  author={Pascal F. Egea and Shu-ou Shan and Johanna Napetschnig and David F Savage and Peter J. Walter and Robert Michael Stroud},
Signal sequences target proteins for secretion from cells or for integration into cell membranes. As nascent proteins emerge from the ribosome, signal sequences are recognized by the signal recognition particle (SRP), which subsequently associates with its receptor (SR). In this complex, the SRP and SR stimulate each other's GTPase activity, and GTP hydrolysis ensures unidirectional targeting of cargo through a translocation pore in the membrane. To define the mechanism of reciprocal activation… CONTINUE READING
Highly Influential
This paper has highly influenced 18 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS


Publications citing this paper.
Showing 1-10 of 135 extracted citations


Publications referenced by this paper.
Showing 1-10 of 39 references

The PyMOL Molecular Graphics System k

  • W. L. DeLano
  • 2003

Structural basis for mobility in the 1.1 Å crystal structure of the NG domain of Thermus aquaticus Ffh

  • Ramirez, D U.
  • J. Mol. Biol
  • 2002

Supplementary Information accompanies the paper on Acknowledgements We thank C. Reyes for invaluable contributions to the initial FtsY mutant design and structure determination

  • A. Philipssen
  • DINO: Visualizing Structural Biology
  • 2002

Similar Papers

Loading similar papers…