Substrate supply for nitric-oxide synthase in macrophages and endothelial cells: role of cationic amino acid transporters.

@article{Closs2000SubstrateSF,
  title={Substrate supply for nitric-oxide synthase in macrophages and endothelial cells: role of cationic amino acid transporters.},
  author={Ellen Ildicho Closs and Jan Stefan Scheld and Mohsen Sharafi and Ulrich Foerstermann},
  journal={Molecular pharmacology},
  year={2000},
  volume={57 1},
  pages={68-74}
}
The current study was designed to investigate the importance of cationic amino acid transporters (CATs) for the L-arginine supply to nitric oxide (NO) synthases in mouse J774A.1 macrophages and human EA.hy926 endothelial cells. CAT-1 was expressed in both cell types, whereas CAT-2B was only expressed in activated macrophages. Apparent K(M) values for… CONTINUE READING